Immunogen
Synthesized peptide derived from NDUFC1 . at AA range: 40-120
Specificity
NDUFC1 Polyclonal Antibody detects endogenous levels of NDUFC1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010],
Function
function:Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.,similarity:Belongs to the complex I NDUFC1 subunit family.,subunit:Complex I is composed of 45 different subunits.,
Protein name
NADH dehydrogenase [ubiquinone] 1 subunit C1 mitochondrial
Other name
NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1; mitochondrial; Complex I-KFYI; CI-KFYI; NADH-ubiquinone oxidoreductase KFYI subunit
Fields
>>Oxidative phosphorylation;>>Metabolic pathways;>>Thermogenesis;>>Retrograde endocannabinoid signaling;>>Non-alcoholic fatty liver disease;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Chemical carcinogenesis - reactive oxygen species;>>Diabetic cardiomyopathy
Human protein sequence Database
O43677
Mouse protein sequence database
Q9CQY9
Rat protein sequence database
Cellular localization
Mitochondrion inner membrane ; Single-pass membrane protein ; Matrix side .
Tissue expression
Brain,Heart,Skin,Umbilical cord blood,
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