Molecular weight (DA)
62kD
Immunogen
The antiserum was produced against synthesized peptide derived from human NEURL1. AA range:219-268
Specificity
Neuralized-1 Polyclonal Antibody detects endogenous levels of Neuralized-1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
NEURL1B (neuralized homolog 1B), also known as neur2 or NEURL3, is a 555 amino acid protein that functions as an E3 ubiquitin-protein ligase. Involved in protein ubiquitination, NEURL1B contains two NHR (neuralized homology repeat) domains and one RING-type zinc finger. NEURL4 (neuralized homolog 4 (Drosophila)), also known as neuralized-like protein 4, is a 1,562 amino acid protein that is highly expressed in a wide variety of tissues. Containing six NHR (neuralized homology repeat) domains, NEURL4 exists as two alternatively spliced isoforms that are encoded by a gene that maps to human chromosome 17p13.1.
Function
microtubule cytoskeleton organization, microtubule bundle formation, reproductive developmental process, cell motion,cytoskeleton organization, microtubule-based process, gamete generation, germ cell development, spermatogenesis,spermatid development, sperm axoneme assembly, lactation, flagellum assembly, cellular component assembly involved in morphogenesis, sexual reproduction, cell projection organization, cell projection assembly, sperm motility,mammary gland development, multicellular organism reproduction, cellular component morphogenesis, axoneme assembly, flagellar axoneme assembly, flagellum organization, male gamete generation, spermatid differentiation,reproductive process in a multicellular organism, reproductive cellular process, gland development, cell motility,localization of cell,
Protein name
Neuralized-like protein 1A
Abbreviation
Neuralized-1
Other name
NEURL; NEURL1; NEURL1A; RNF67; Neuralized-like protein 1A; h-neu; h-neuralized 1; RING finger protein 67
Human protein sequence Database
O76050
Mouse protein sequence database
Q923S6
Rat protein sequence database
Cellular localization
Cytoplasm, perinuclear region . Cell membrane ; Peripheral membrane protein . Perikaryon . Cell projection, dendrite . Cell junction, synapse, postsynaptic density . Localized in the cell bodies of the pyramidal neurons and distributed along their apical dendrites. Colocalized with PSD95 in postsynaptic sites. Colocalized with CPEB3 at apical dendrites of CA1 neurons (By similarity). Colocalized with JAG1 at the cell surface. .
Tissue expression
Expressed in brain, testis, pituitary gland, pancreas and bone marrow. Also poorly expressed in malignant astrocytomas and several neuroectodermal tumor cell lines. Weakly expressed in medulloblastoma (MB) compared with normal cerebellar tissues.
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