Molecular weight (DA)
50kD
Immunogen
Synthesized peptide derived from PDK1 . at AA range: 80-160
Specificity
PDK1 Polyclonal Antibody detects endogenous levels of PDK1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013],
Function
catalytic activity:ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.,function:Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.,similarity:Belongs to the PDK/BCKDK protein kinase family.,similarity:Contains 1 histidine kinase domain.,tissue specificity:Expressed predominantly in the heart.,
Protein name
[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1 mitochondrial
Other name
PDK1; PDHK1; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1; mitochondrial; Pyruvate dehydrogenase kinase isoform 1
Fields
>>HIF-1 signaling pathway;>>Central carbon metabolism in cancer
Human protein sequence Database
Q15118
Mouse protein sequence database
Q8BFP9
Rat protein sequence database
Q63065
Cellular localization
Mitochondrion matrix .
Tissue expression
Expressed predominantly in the heart. Detected at lower levels in liver, skeletal muscle and pancreas.
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