Molecular weight (DA)
25kD
Immunogen
The antiserum was produced against synthesized peptide derived from human TIMP3. AA range:91-140
Specificity
TIMP-3 Polyclonal Antibody detects endogenous levels of TIMP-3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008],
Function
disease:Defects in TIMP3 are the cause of Sorsby fundus dystrophy (SFD) [MIM:136900]. SFD is a rare autosomal dominant macular disorder with an age of onset in the fourth decade. It is characterized by loss of central vision from subretinal neovascularization and atrophy of the ocular tissues. Generally, macular disciform degeneration develops in the patients eye within 6 months to 6 years.,function:Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.,online information:Retina International's Scientific Newsletter,similarity:Belongs to the protease inhibitor I35 (TIMP) family.,similarity:Contains 1 NTR domain.,
Protein name
Metalloproteinase inhibitor 3
Other name
TIMP3; Metalloproteinase inhibitor 3; Protein MIG-5; Tissue inhibitor of metalloproteinases 3; TIMP-3
Fields
>>Proteoglycans in cancer;>>MicroRNAs in cancer
Human protein sequence Database
P35625
Mouse protein sequence database
P39876
Rat protein sequence database
P48032
Cellular localization
Secreted, extracellular space, extracellular matrix.
Tissue expression
Kidney,Mammary carcinoma,Pancreas,Placenta,Retina,Uterus,
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