Molecular weight (DA)
81kD
Immunogen
The antiserum was produced against synthesized peptide derived from human USP44. AA range:211-260
Specificity
USP44 Polyclonal Antibody detects endogenous levels of USP44 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP44 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008],
Function
catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 UBP-type zinc finger.,tissue specificity:Expressed in testis.,
Protein name
Ubiquitin carboxyl-terminal hydrolase 44
Other name
USP44; Ubiquitin carboxyl-terminal hydrolase 44; Deubiquitinating enzyme 44; Ubiquitin thioesterase 44; Ubiquitin-specific-processing protease 44
Human protein sequence Database
Q9H0E7
Mouse protein sequence database
Q8C2S0
Rat protein sequence database
Cellular localization
Nucleus . Peaks in interphase, with relatively low levels maintained throughout mitosis. .
Tissue expression
Expressed in testis. Expressed at high levels in T-cell acute lymphoblastic leukemia.
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