Molecular weight (DA)
76kD
Immunogen
Purified recombinant human Annexin VI protein fragments expressed in E.coli.
Specificity
This antibody detects endogenous levels of Annexin VI and does not cross-react with related proteins.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Background
Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010],
Function
caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,domain:A pair of annexin repeats may form one binding site for calcium and phospholipid.,function:May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.,induction:By EBV.,miscellaneous:Seems to bind one calcium ion with high affinity.,PTM:Phosphorylated in response to growth factor stimulation.,similarity:Belongs to the annexin family.,similarity:Contains 4 annexin repeats.,similarity:Contains 8 annexin repeats.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,
Other name
67 kDa calelectrin;Annexin A6;Annexin VI;Annexin VI p68;Annexin-6;AnnexinA6;AnnexinVI; ANX 6;ANX A6;ANX6;ANXA6;ANXA6_HUMAN;Calcium binding protein p68;Calelectrin;Calphobindin II;Calphobindin-II;CalphobindinII;CBP 68;Chromobindin 20;CPBII;Lipocortin VI; LipocortinVI;Protein III;ProteinIII.
Human protein sequence Database
P08133
Mouse protein sequence database
P14824
Rat protein sequence database
Cellular localization
Cytoplasm . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Tissue expression
Adipocyte,Amygdala,Lung,Uterus,
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