Molecular weight (DA)
60kD
Immunogen
Synthesized peptide derived from human LCTL AA range: 450-500
Specificity
This antibody detects endogenous levels of LCTL at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.143% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of family 1 glycosidases. Glycosidases are enzymes that hydrolyze glycosidic bonds and are classified into families based on primary amino acid sequence. Most members of family 1 have two conserved glutamic acid residues, which are required for enzymatic activity. The mouse ortholog of this protein has been characterized and has a domain structure of an N-terminal signal peptide, glycosidase domain, transmembrane domain, and a short cytoplasmic tail. It lacks one of the conserved glutamic acid residues important for catalysis, and its function remains to be determined (PMID: 12084582). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013],
Function
caution:Probably inactive as a glycosidase since it lacks the essential active site Glu at position 201.,similarity:Belongs to the glycosyl hydrolase 1 family.,similarity:Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.,
Gene Name
LCTL KLPH UNQ3022/PRO9820
Other name
Lactase-like protein (Klotho/lactase-phlorizin hydrolase-related protein)
Human protein sequence Database
Q6UWM7
Mouse protein sequence database
Q8K1F9
Rat protein sequence database
Cellular localization
Endoplasmic reticulum membrane ; Single-pass membrane protein .
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