Molecular weight (DA)
46kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ARRDC3. AA range:365-414
Specificity
ARRDC3 Polyclonal Antibody detects endogenous levels of ARRDC3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the arrestin family of proteins, which regulate G protein-mediated signaling. The encoded protein is thought to act as a regulator of breast cancer growth and progression by binding to a phosphorylated form of integrin beta4, a tumor-related antigen, targeting the integrin for internalization and degradation. [provided by RefSeq, Jul 2016],
Function
induction:By troglitazone and pioglitazone (selective PPARG agonists), by prostaglandin J2 (PGJ2) and by L165,041 (a PPARD ligand), by vitamin D3 and, to a lesser extent, by PMA (phorbol myristate acetate) in the promyelocytic leukemia HL-60 cells. No induction by retinoic acid, nor by clofibrate (a specific PPARA agonist).,similarity:Belongs to the arrestin family.,subcellular location:Associated with plasma membrane, as well as with endodomes and lysosomes during endocytosis.,subunit:Does not bind TXN (thioredoxin).,tissue specificity:Highly expressed in skeletal muscle, placenta, kidney, adrenal gland, lymph node, mammary gland, thyroid, and trachea. Very low levels in colon, thymus, spleen, small intestine, bladder and bone marrow. Strong expression in differentiated adipocytes compared to preadipocytes.,
Protein name
Arrestin domain-containing protein 3
Other name
ARRDC3; KIAA1376; Arrestin domain-containing protein 3; TBP-2-like inducible membrane protein; TLIMP
Human protein sequence Database
Q96B67
Mouse protein sequence database
Q7TPQ9
Rat protein sequence database
Q6TXF1
Cellular localization
Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Lysosome . Endosome . Early endosome . Associated with plasma membrane, as well as with endosomes and lysosomes during endocytosis (PubMed:16269462, PubMed:23208550, PubMed:20559325). .
Tissue expression
Highly expressed in skeletal muscle, placenta, kidney, lung, liver, blood, adrenal gland, lymph node, mammary gland, thyroid, and trachea (PubMed:16269462, PubMed:21982743). Very low levels in colon, thymus, spleen, small intestine, bladder and bone marrow (PubMed:16269462). Strong expression in differentiated adipocytes compared to preadipocytes (PubMed:16269462). Detected in omental fat and subcutaneous fat tissue (PubMed:21982743).
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车