Molecular weight (DA)
11kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Stefin A. AA range:49-98
Specificity
Cystatin A Polyclonal Antibody detects endogenous levels of Cystatin A protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer. [provided by RefSeq, Jul 2008],
Function
function:This is an intracellular thiol proteinase inhibitor.,similarity:Belongs to the cystatin family.,
Other name
CSTA; STF1; STFA; Cystatin-A; Cystatin-AS; Stefin-A
Human protein sequence Database
P01040
Mouse protein sequence database
P56567
Rat protein sequence database
Cellular localization
Cytoplasm .
Tissue expression
Expressed in the skin throughout the epidermis.
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