Molecular weight (DA)
65kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ME2. AA range:201-250
Specificity
ME2 Polyclonal Antibody detects endogenous levels of ME2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq, Dec 2009],
Function
catalytic activity:(S)-malate + NAD(+) = pyruvate + CO(2) + NADH.,cofactor:Divalent metal cations. Prefers magnesium or manganese.,enzyme regulation:Subject to allosteric activation by fumarate.,miscellaneous:This isoenzyme can also use NADP(+) but is more effective with NAD(+).,similarity:Belongs to the malic enzymes family.,subunit:Homotetramer.,
Protein name
NAD-dependent malic enzyme mitochondrial
Other name
ME2; NAD-dependent malic enzyme; mitochondrial; NAD-ME; Malic enzyme 2
Fields
>>Pyruvate metabolism;>>Carbon metabolism
Human protein sequence Database
P23368
Mouse protein sequence database
Q99KE1
Rat protein sequence database
Cellular localization
Mitochondrion matrix .
Tissue expression
B-cell,Placenta,Platelet,
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