Molecular weight (DA)
24kD
Immunogen
The antiserum was produced against synthesized peptide derived from human MRPL22. AA range:91-140
Specificity
MRP-L22 Polyclonal Antibody detects endogenous levels of MRP-L22 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L22 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 4q. Two transcript variants encoding different isoforms have been found for this gene. [provide
Function
similarity:Belongs to the ribosomal protein L22P family.,
Protein name
39S ribosomal protein L22 mitochondrial
Other name
MRPL22; MRPL25; RPML25; HSPC158; 39S ribosomal protein L22; mitochondrial; L22mt; MRP-L22; 39S ribosomal protein L25, mitochondrial; L25mt; MRP-L25
Human protein sequence Database
Q9NWU5
Mouse protein sequence database
Q8BU88
Rat protein sequence database
P0C2C0
Cellular localization
Mitochondrion .
Tissue expression
Carcinoma,Retina,Skin,Testis,Umbilical cord blood,
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