Molecular weight (DA)
27kD
Immunogen
Synthesized peptide derived from the Internal region of human Chymase.
Specificity
Chymase Polyclonal Antibody detects endogenous levels of Chymase protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
chymase 1(CMA1) Homo sapiens This gene encodes a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants. [provided by RefSeq, Apr 2015],
Function
catalytic activity:Preferential cleavage: Phe-|-Xaa > Tyr-|-Xaa > Trp-|-Xaa > Leu-|-Xaa.,function:Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.,similarity:Belongs to the peptidase S1 family.,similarity:Belongs to the peptidase S1 family. Granzyme subfamily.,similarity:Contains 1 peptidase S1 domain.,subcellular location:Mast cell granules.,tissue specificity:Mast cells in lung, heart, skin and placenta.,
Other name
CMA1; CYH; CYM; Chymase; Alpha-chymase; Mast cell protease I
Fields
>>Renin-angiotensin system;>>Diabetic cardiomyopathy
Human protein sequence Database
P23946
Mouse protein sequence database
P21844
Rat protein sequence database
Cellular localization
Secreted. Cytoplasmic granule. Mast cell granules.
Tissue expression
Mast cells in lung, heart, skin and placenta. Expressed in both normal skin and in urticaria pigmentosa lesions.
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