Molecular weight (DA)
26kD
Immunogen
The antiserum was produced against synthesized peptide derived from human FFAR1. AA range:185-234
Specificity
GPR40 Polyclonal Antibody detects endogenous levels of GPR40 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provided by RefSeq, Apr 2009],
Function
function:Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G-proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated pathway.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed abundantly in pancreatic beta cells.,
Protein name
Free fatty acid receptor 1
Other name
FFAR1; GPR40; Free fatty acid receptor 1; G-protein coupled receptor 40
Fields
>>Insulin secretion
Human protein sequence Database
O14842
Mouse protein sequence database
Q76JU9
Rat protein sequence database
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Detected in brain and pancreas. Detected in pancreatic beta cells.
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