Molecular weight (DA)
55/48kD
Immunogen
Recombinant protein corresponding to full length Keratin8 of human.
Specificity
This antibody detects endogenous levels of keratin8/18.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000, ICC 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Background
keratin 8(KRT8) Homo sapiens This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012],
Function
disease:Defects in KRT8 are a cause of cryptogenic cirrhosis [MIM:215600].,function:Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,PTM:O-glycosylated at multiple sites; glycans consist of single N-acetylglucosamine residues.,PTM:Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins. keratin-8 associates with keratin-18. Associates with KRT20. Interacts with HCV core protein and PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP.,tissue spec
Abbreviation
Cytokeratin 8
Other name
card2;Cardiac autoantigen 2 120kD;CK 8;CK-8;ck8;Cyk 8;cyk8;CYKER;Cytokeratin 8;Cytokeratin endo A;Cytokeratin-8; Cytokeratin8; DreK8;EndoA; k0;k2c8; K2C8_HUMAN;k8;Keratin 8;Keratin type ii cytoskeletal 8;Keratin, type II cytoskeletal 8;Keratin-8;Keratin8;KO;Krt 2.8;Krt8; krt8;MGC118110;MGC174782;MGC53564;MGC85764;sb:cb186;Type-II keratin Kb8./Cell proliferation inducing gene 46 protein;Cell proliferation inducing protein 46;Cell proliferation-inducing gene 46 protein;CK 18;CK-18;CK18;CYK 18;CYK18;Cytokeratin 18;Cytokeratin endo B;Cytokeratin-18;K 18;K18;K1C18_HUMAN;Keratin 18;Keratin D;keratin, type I cytoskeletal 18;Keratin-18;KRT18.
Human protein sequence Database
P05787/P05783
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus, nucleoplasm . Nucleus matrix .
Tissue expression
Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
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