Molecular weight (DA)
79kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 70-150
Specificity
GTSE1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008],
Function
developmental stage:Expressed in G2/M phase. Not detected in quiescent cells.,function:May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression.,PTM:Phosphorylated in mitosis.,subcellular location:Associated with microtubules.,
Protein name
G2 and S phase-expressed protein 1 (GTSE-1) (Protein B99 homolog)
Fields
>>p53 signaling pathway
Human protein sequence Database
Q9NYZ3
Mouse protein sequence database
Q8R080
Rat protein sequence database
Cellular localization
Cytoplasm, cytoskeleton. Associated with microtubules.
Tissue expression
Brain,Epithelium,Liver,Muscle,Placenta,
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