Molecular weight (DA)
152kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
CNTP1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
contactin associated protein 1(CNTNAP1) Homo sapiens The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein,' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. [provided by RefSeq, Jan 2009],
Function
function:Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells.,similarity:Belongs to the neurexin family.,similarity:Contains 1 F5/8 type C domain.,similarity:Contains 1 fibrinogen C-terminal domain.,similarity:Contains 2 EGF-like domains.,similarity:Contains 4 laminin G-like domains.,subunit:Interacts with contactin in cis form.,tissue specificity:Predominantly expressed in brain. Weak expression detected in ovary, pancreas, colon, lung, heart, intestine and testis.,
Gene Name
CNTNAP1 CASPR NRXN4
Protein name
Contactin-associated protein 1 (Caspr) (Caspr1) (Neurexin IV) (Neurexin-4) (p190)
Fields
>>Cell adhesion molecules
Human protein sequence Database
P78357
Mouse protein sequence database
O54991
Rat protein sequence database
P97846
Cellular localization
Membrane ; Single-pass type I membrane protein . Cell junction, paranodal septate junction .
Tissue expression
Predominantly expressed in brain. Weak expression detected in ovary, pancreas, colon, lung, heart, intestine and testis.
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