Molecular weight (DA)
116kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
DNA2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the DNA2/NAM7 helicase family. The encoded protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. Mutations in this gene are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014],
Function
function:May function in chromosomal DNA replication.,similarity:Belongs to the DNA2/NAM7 helicase family.,
Gene Name
DNA2 DNA2L KIAA0083
Protein name
DNA replication ATP-dependent helicase/nuclease DNA2 (hDNA2) (DNA replication ATP-dependent helicase-like homolog) [Includes: DNA replication nuclease DNA2 (EC 3.1.-.-); DNA replication ATP-dependent
Human protein sequence Database
P51530
Mouse protein sequence database
Q6ZQJ5
Rat protein sequence database
D3ZG52
Cellular localization
Nucleus. Mitochondrion. Was initially reported to be exclusively mitochondrial (PubMed:18995831). However, it was later shown to localize both in mitochondrion and nucleus (PubMed:19487465). .
Tissue expression
Bone marrow,Colon,Duodenum,Lymph,
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