Molecular weight (DA)
41kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
TEFF1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
function:May inhibit NODAL and BMP signaling during neural patterning (By similarity). May be a tumor suppressor in brain cancers.,similarity:Belongs to the tomoregulin family.,similarity:Belongs to the UPF0439 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 2 Kazal-like domains.,subunit:May interact with ST14.,tissue specificity:Expressed in brain.,tissue specificity:Expressed predominantly in brain, and at lower levels in heart, placenta and skeletal muscle. Down-regulated in brain tumors as compared to control brain tissues.,
Function
function:May inhibit NODAL and BMP signaling during neural patterning (By similarity). May be a tumor suppressor in brain cancers.,similarity:Belongs to the tomoregulin family.,similarity:Belongs to the UPF0439 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 2 Kazal-like domains.,subunit:May interact with ST14.,tissue specificity:Expressed in brain.,tissue specificity:Expressed predominantly in brain, and at lower levels in heart, placenta and skeletal muscle. Down-regulated in brain tumors as compared to control brain tissues.,
Protein name
Tomoregulin-1 (TR-1) (H7365) (Transmembrane protein with EGF-like and one follistatin-like domain)
Human protein sequence Database
Q8IYR6
Mouse protein sequence database
Q6PFE7
Rat protein sequence database
Q9QYV1
Cellular localization
Cell membrane ; Single-pass type I membrane protein .
Tissue expression
Expressed predominantly in brain, and at lower levels in heart, placenta and skeletal muscle. Down-regulated in brain tumors as compared to control brain tissues.
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