Molecular weight (DA)
125kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
MCF2L Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a guanine nucleotide exchange factor that interacts specifically with the GTP-bound Rac1 and plays a role in the Rho/Rac signaling pathways. A variant in this gene was associated with osteoarthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],
Function
domain:The CRAL-TRIO domain is involved in interaction with inositol phospholipids.,domain:The DH domain is involved in interaction with CCPG1.,function:Guanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42.,similarity:Belongs to the MCF2 family.,similarity:Contains 1 CRAL-TRIO domain.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 1 spectrin repeat.,subunit:Interacts with CCPG1, which results in specific inhibiti
Protein name
Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2-transforming sequence-like protein)
Human protein sequence Database
O15068
Mouse protein sequence database
Q64096
Rat protein sequence database
Q63406
Cellular localization
[Isoform 5]: Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side .; [Isoform 3]: Cytoplasm . Endomembrane system . Interaction with membranes enriched in phosphoinositides is mediated by the CRAL-TRIO domain. .; Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side .
Tissue expression
Amygdala,Brain,Muscle,PCR rescued clones,
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