Molecular weight (DA)
102kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 260-340
Specificity
OSBL6 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
Function
PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the OSBP family.,similarity:Contains 1 PH domain.,tissue specificity:Widely expressed.,
Protein name
Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6)
Human protein sequence Database
Q9BZF3
Mouse protein sequence database
Q8BXR9
Rat protein sequence database
Cellular localization
Cytoplasm, cytosol . Endoplasmic reticulum membrane ; Peripheral membrane protein . Nucleus envelope . Cell membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Co-localizes with OSBPL3 at contact sites between the plasma membrane and the endoplasmic reticulum. .
Tissue expression
Expressed in brain and striated muscle (at protein level) (PubMed:14593528). Widely expressed (PubMed:11735225). Expressed in skeletal muscle (PubMed:14593528).
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