Molecular weight (DA)
50kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human CRHR1. AA range:71-120
Specificity
CRF-RI Polyclonal Antibody detects endogenous levels of CRF-RI protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Naturally-occurring readthrough transcription between this gene and upstream GeneID:147081 results in transcripts that encode isoforms that share similarity with the products of this gene. [provided by RefSeq, Aug 2016],
Function
function:This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.,PTM:C-terminal Ser or Thr residues may be phosphorylated.,similarity:Belongs to the G-protein coupled receptor 2 family.,tissue specificity:Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe.,
Protein name
Corticotropin-releasing factor receptor 1
Other name
CRHR1; CRFR; CRFR1; CRHR; Corticotropin-releasing factor receptor 1; CRF-R-1; CRF-R1; CRFR-1; Corticotropin-releasing hormone receptor 1; CRH-R-1; CRH-R1
Fields
>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Long-term depression;>>Cushing syndrome
Human protein sequence Database
P34998
Mouse protein sequence database
P35347
Rat protein sequence database
P35353
Cellular localization
Cell membrane; Multi-pass membrane protein. Endosome. Agonist-binding promotes endocytosis.
Tissue expression
Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe.
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