Molecular weight (DA)
43kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 270-350
Specificity
PI5L1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
PIP5KL1 is a phosphoinositide kinase-like protein that lacks intrinsic lipid kinase activity but associates with type I PIPKs (see PIP5K1A; MIM 603275) and may play a role in localization of PIPK activity (Chang et al., 2004 [PubMed 14701839]).[supplied by OMIM, Jun 2009],
Function
catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.,caution:It is unsure if the enzyme has intrinsic kinase activity.,function:May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3.,similarity:Contains 1 PI5K domain.,subcellular location:Localized to large cytoplasmic vesicular structures.,subunit:Heterodimerizes with other type I phosphatidylinositol-4-phosphate 5-kinase.,
Protein name
Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 (PI(4)P 5-kinase-like protein 1) (PtdIns(4)P-5-kinase-like protein 1) (EC 2.7.1.68)
Fields
>>Inositol phosphate metabolism;>>Metabolic pathways;>>Endocytosis
Human protein sequence Database
Q5T9C9
Mouse protein sequence database
Q6U7H8
Rat protein sequence database
Cellular localization
Cytoplasm. Membrane. Localized to large cytoplasmic vesicular structures. .
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