Molecular weight (DA)
46kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
SGK2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010],
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,caution:Not regulated by serum or glucocorticoids.,enzyme regulation:Two specific sites, one in the kinase domain (Thr-253) and the other in the C-terminal regulatory region (Ser-416), need to be phosphorylated for its full activation.,function:Involved in the activation of potassium channels.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,tissue specificity:Highly expressed in liver, kidney and pancreas, and at lower levels in brain.,
Protein name
Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2)
Fields
>>FoxO signaling pathway;>>PI3K-Akt signaling pathway
Human protein sequence Database
Q9HBY8
Mouse protein sequence database
Q9QZS5
Rat protein sequence database
Q8R4U9
Cellular localization
Cytoplasm . Nucleus .
Tissue expression
Highly expressed in liver, kidney and pancreas, and at lower levels in brain.
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