Molecular weight (DA)
87kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
TRPC1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
transient receptor potential cation channel subfamily C member 1(TRPC1) Homo sapiens The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
Function
function:Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.,similarity:Belongs to the transient receptor family. STrpC subfamily.,similarity:Contains 3 ANK repeats.,subunit:Interacts with TRPC3. Interacts with ITPR3. Interacts with MX1 and RNF24.,tissue specificity:Seems to be ubiquitous.,
Protein name
Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (TRP-1)
Fields
>>Axon guidance;>>Glutamatergic synapse;>>Serotonergic synapse;>>GnRH secretion;>>Pancreatic secretion
Human protein sequence Database
P48995
Mouse protein sequence database
Q61056
Rat protein sequence database
Q9QX01
Cellular localization
Membrane; Multi-pass membrane protein.
Tissue expression
Seems to be ubiquitous.
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