Molecular weight (DA)
240kD
Immunogen
The antiserum was produced against synthesized peptide derived from the C-terminal region of human TNC. AA range:2151-2200
Specificity
Tenascin-C Polyclonal Antibody detects endogenous levels of Tenascin-C protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
tenascin C(TNC) Homo sapiens This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011],
Function
alternative products:Isoforms are produced in a tissue- and time-specific manner during development,function:Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.,induction:By TGF-beta.,PTM:N-glycosylated.,similarity:Belongs to the tenascin family.,similarity:Contains 1 fibrinogen C-terminal domain.,similarity:Contains 15 EGF-like domains.,similarity:Contains 15 fibronectin type-III domains.,subunit:Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the ce
Other name
TNC; HXB; Tenascin; TN; Cytotactin; GMEM; GP 150-225; Glioma-associated-extracellular matrix antigen; Hexabrachion; JI; Myotendinous antigen; Neuronectin; Tenascin-C; TN-C
Fields
>>PI3K-Akt signaling pathway;>>Focal adhesion;>>ECM-receptor interaction;>>Human papillomavirus infection;>>MicroRNAs in cancer
Human protein sequence Database
P24821
Mouse protein sequence database
Q80YX1
Rat protein sequence database
Cellular localization
Secreted, extracellular space, extracellular matrix.
Tissue expression
Brain,Fetal brain,Fetal cartilage,Glioblastoma,Human fetal kidney,Liver,Melanoma,Milk,Plasma,
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