Molecular weight (DA)
100kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 560-640
Specificity
E2F7 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
E2F transcription factors, such as E2F7, play an essential role in the regulation of cell cycle progression (Di Stefano et al., 2003 [PubMed 14633988]).[supplied by OMIM, May 2008],
Function
domain:Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer.,function:Along with E2F8, inhibitor of E2F-dependent transcription that is important for the control of the E2F1-TP53 apoptotic pathway. Directly represses E2F1 transcription (By similarity). Binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession.,similarity:Belongs to the E2F/DP family.,subunit:Forms homodimers and, to a lesser extent, heterodimers with E2F8. Dimerization is important for DNA binding.,
Protein name
Transcription factor E2F7 (E2F-7)
Human protein sequence Database
Q96AV8
Mouse protein sequence database
Q6S7F2
Rat protein sequence database
Cellular localization
Nucleus .
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