Immunogen
Synthesized phospho-peptide around the phosphorylation site of human CdGAP (phospho Thr789)
Specificity
Phospho-CdGAP (T789) Polyclonal Antibody detects endogenous levels of CdGAP protein only when phosphorylated at T789.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a GTPase-activating protein (GAP). A variety of cellular processes are regulated by Rho GTPases which cycle between an inactive form bound to GDP and an active form bound to GTP. This cycling between inactive and active forms is regulated by guanine nucleotide exchange factors and GAPs. The encoded protein is a GAP shown to regulate two GTPases involved in protein trafficking and cell growth. [provided by RefSeq, Jul 2008],
Function
developmental stage:Mainly expressed in fetal heart and muscle.,function:Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration.,PTM:Phosphorylation on Thr-789 reduces GAP activity.,similarity:Contains 1 Rho-GAP domain.,subunit:Interacts with ITSN1, which inhibits GAP activity. Interacts with PARVA.,
Protein name
Rho GTPase-activating protein 31
Other name
ARHGAP31; CDGAP; KIAA1204; Rho GTPase-activating protein 31; Cdc42 GTPase-activating protein
Human protein sequence Database
Q9ULL6
Mouse protein sequence database
Rat protein sequence database
Cellular localization
cytosol,focal adhesion,lamellipodium,
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