Molecular weight (DA)
79kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
ESRP2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
epithelial splicing regulatory protein 2(ESRP2) Homo sapiens ESPR2 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009],
Function
function:mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.,induction:Down-regulated during the epithelial-to-mesenchymal transition (EMT).,similarity:Belongs to the ESRP family.,similarity:Contains 3 RRM (RNA recognition motif) domains.,tissue specificity:Epithelial cell-specific.,
Gene Name
ESRP2 RBM35B PP7059
Protein name
Epithelial splicing regulatory protein 2 (RNA-binding motif protein 35B) (RNA-binding protein 35B)
Human protein sequence Database
Q9H6T0
Mouse protein sequence database
Q8K0G8
Rat protein sequence database
B2RYJ8
Cellular localization
Nucleus .
Tissue expression
Epithelial cell-specific.
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