Molecular weight (DA)
25kD
Immunogen
Synthesized peptide derived from part region of human protein AA range: 21-70
Specificity
FAM3B Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
function:Has delayed effects on beta-cell function, inhibiting basal insulin secretion from a beta-cell line in a dose-dependent manner.,miscellaneous:2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46.,similarity:Belongs to the FAM3 family.,subcellular location:Localized in discrete vesicular and perinuclear structure.,tissue specificity:Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis.,
Function
function:Has delayed effects on beta-cell function, inhibiting basal insulin secretion from a beta-cell line in a dose-dependent manner.,miscellaneous:2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46.,similarity:Belongs to the FAM3 family.,subcellular location:Localized in discrete vesicular and perinuclear structure.,tissue specificity:Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis.,
Gene Name
FAM3B C21orf11 C21orf76 PRED44 UNQ320/PRO365
Protein name
Protein FAM3B (Cytokine-like protein 2-21) (Pancreatic-derived factor) (PANDER)
Human protein sequence Database
P58499
Mouse protein sequence database
Q9D309
Rat protein sequence database
Cellular localization
Secreted. Present in insulin secretory granules and likely cosecreted with insulin. Localized in discrete vesicular and perinuclear structure.
Tissue expression
Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis.
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