Molecular weight (DA)
14kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 20-100
Specificity
TKN1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Substance P is an antimicrobial peptide with antibacterial and antifungal properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014],
Function
function:Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.,online information:Neurokinin-1 entry,similarity:Belongs to the tachykinin family.,
Gene Name
TAC1 NKA NKNA TAC2
Protein name
Protachykinin-1 (PPT) [Cleaved into: Substance P; Neurokinin A (NKA) (Neuromedin L) (Substance K); Neuropeptide K (NPK); Neuropeptide gamma; C-terminal-flanking peptide]
Fields
>>Neuroactive ligand-receptor interaction
Human protein sequence Database
P20366
Mouse protein sequence database
P41539
Rat protein sequence database
P06767
Cellular localization
Secreted.
Tissue expression
Adrenal medulla,Blood,Brain,Small intestine,Testis,
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