Molecular weight (DA)
64kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 270-350
Specificity
ACM3 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. [provided by RefSeq, Jul 2008],
Function
function:The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.,similarity:Belongs to the G-protein coupled receptor 1 family.,
Protein name
Muscarinic acetylcholine receptor M3
Fields
>>Calcium signaling pathway;>>Neuroactive ligand-receptor interaction;>>Cholinergic synapse;>>Taste transduction;>>Regulation of actin cytoskeleton;>>Insulin secretion;>>Salivary secretion;>>Gastric acid secretion;>>Pancreatic secretion;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases
Human protein sequence Database
P20309
Mouse protein sequence database
Q9ERZ3
Rat protein sequence database
P08483
Cellular localization
Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein . Basolateral cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Colocalizes with TMEM147 in the endoplasmic reticulum (ER) membrane. TMEM147 impairs its trafficking to the cell membrane leading to its retention in the ER membrane. .
Tissue expression
Brain,Teratocarcinoma,
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