Molecular weight (DA)
46kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
MCHR1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
melanin concentrating hormone receptor 1(MCHR1) Homo sapiens The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. [provided by RefSeq, Jul 2008],
Function
caution:It is uncertain whether Met-1, Met-6 or Met-70 is the initiator.,function:Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with NCDN.,tissue specificity:Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart.,
Gene Name
MCHR1 GPR24 SLC1
Protein name
Melanin-concentrating hormone receptor 1 (MCH receptor 1) (MCH-R1) (MCHR-1) (G-protein coupled receptor 24) (MCH-1R) (MCH1R) (MCHR) (SLC-1) (Somatostatin receptor-like protein)
Fields
>>Neuroactive ligand-receptor interaction
Human protein sequence Database
Q99705
Mouse protein sequence database
Q8JZL2
Rat protein sequence database
P97639
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart.
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