Molecular weight (DA)
40kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 200-280
Specificity
OPSG Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called green cone photopigment or medium-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. The long-wavelength opsin gene and multiple copies of the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of deutanopic colorblindness. [provided by RefSeq, Mar 2009],
Function
disease:Defects in OPN1MW are the cause of partial colorblindness deutan series (CBD) [MIM:303800]; also called deuteranopia.,function:Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.,online information:Retina International's Scientific Newsletter,PTM:Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.,similarity:Belongs to the G-protein coupled receptor 1 family.,similarity:Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.,tissue specificity:The three color pigments are found in the cone photoreceptor cells.,
Gene Name
OPN1MW GCP; OPN1MW2
Protein name
Medium-wave-sensitive opsin 1 (Green cone photoreceptor pigment) (Green-sensitive opsin) (GOP)
Human protein sequence Database
P04001
Mouse protein sequence database
O35599
Rat protein sequence database
O35476
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
The three color pigments are found in the cone photoreceptor cells.
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