Molecular weight (DA)
33kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
UCP1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008],
Function
function:UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.,polymorphism:The Thr-64 polymorphism is associated with an increased waist-to-hip ratio. The Leu-229 polymorphism is associated with susceptibility to type II diabetes mellitus.,similarity:Belongs to the mitochondrial carrier family.,similarity:Contains 3 Solcar repeats.,subunit:Acts as a dimer forming a proton channel.,tissue specificity:Brown adipose tissue.,
Gene Name
UCP1 SLC25A7 UCP
Protein name
Mitochondrial brown fat uncoupling protein 1 (UCP 1) (Solute carrier family 25 member 7) (Thermogenin)
Fields
>>PPAR signaling pathway;>>Apelin signaling pathway;>>Thermogenesis;>>Huntington disease
Human protein sequence Database
P25874
Mouse protein sequence database
P12242
Rat protein sequence database
P04633
Cellular localization
Mitochondrion inner membrane ; Multi-pass membrane protein .
Tissue expression
Brown adipose tissue.
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