Molecular weight (DA)
41kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
SIA8B Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29. [provided by RefSeq, Jul 2008],
Function
function:May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression.,online information:GlycoGene database,online information:ST8Sia II,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 29 family.,tissue specificity:Highly expressed in fetal brain, kidney and heart and to a much lesser extent in adult heart and thymus.,
Gene Name
ST8SIA2 SIAT8B STX
Protein name
Alpha-2,8-sialyltransferase 8B (EC 2.4.99.-) (Sialyltransferase 8B) (SIAT8-B) (Sialyltransferase X) (STX) (Sialytransferase St8Sia II) (ST8SiaII)
Human protein sequence Database
Q92186
Mouse protein sequence database
O35696
Rat protein sequence database
Q07977
Cellular localization
Golgi apparatus membrane ; Single-pass type II membrane protein .
Tissue expression
Highly expressed in fetal brain, kidney and heart and to a much lesser extent in adult heart and thymus.
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