Molecular weight (DA)
64kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
VGLU2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
developmental stage:Expressed in fetal brain.,function:Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.,similarity:Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.,tissue specificity:Predominantly expressed in adult brain. Expressed in amygdala, caudate nucleus, cerebral cortex, frontal lobe, hippocampus, medulla, occipital lobe, puteman, spinal cord, substantia nigra, subthalamic nucleus, temporal lobe and thalamus.,
Function
developmental stage:Expressed in fetal brain.,function:Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.,similarity:Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.,tissue specificity:Predominantly expressed in adult brain. Expressed in amygdala, caudate nucleus, cerebral cortex, frontal lobe, hippocampus, medulla, occipital lobe, puteman, spinal cord, substantia nigra, subthalamic nucleus, temporal lobe and thalamus.,
Gene Name
SLC17A6 DNPI VGLUT2
Protein name
Vesicular glutamate transporter 2 (VGluT2) (Differentiation-associated BNPI) (Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 6)
Fields
>>Synaptic vesicle cycle;>>Retrograde endocannabinoid signaling;>>Glutamatergic synapse;>>Nicotine addiction
Human protein sequence Database
Q9P2U8
Mouse protein sequence database
Q8BLE7
Rat protein sequence database
Q9JI12
Cellular localization
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein . Cell junction, synapse, synaptosome .
Tissue expression
Predominantly expressed in adult brain (PubMed:10820226). Expressed in amygdala, caudate nucleus, cerebral cortex, frontal lobe, hippocampus, medulla, occipital lobe, putamen, spinal cord, substantia nigra, subthalamic nucleus, temporal lobe and thalamus (PubMed:10820226).
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