Molecular weight (DA)
38kD
Immunogen
Synthesized peptide derived from human KLF2 AA range: 196-246
Specificity
This antibody detects endogenous levels of KLF2 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.70% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Kruppel-like factors (KLFs) are a family of broadly expressed zinc finger transcription factors. KLF2 regulates T-cell trafficking by promoting expression of the lipid-binding receptor S1P1 (S1PR1; MIM 601974) and the selectin CD62L (SELL; MIM 153240) (summary by Weinreich et al., 2009 [PubMed 19592277]).[supplied by OMIM, Feb 2011],
Function
function:Binds to the CACCC box in the beta-globin gene promoter and activates transcription.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,subunit:Interacts with WWP1.,
Other name
Krueppel-like factor 2 (Lung krueppel-like factor)
Fields
>>FoxO signaling pathway;>>Apelin signaling pathway;>>Fluid shear stress and atherosclerosis
Human protein sequence Database
Q9Y5W3
Mouse protein sequence database
Q60843
Rat protein sequence database
Q9ET58
Cellular localization
Nucleus .
Tissue expression
Brain,Hair follicle dermal papilla,Lung,Spleen,
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