Molecular weight (DA)
60kD
Immunogen
Synthesized peptide derived from human EST4A AA range: 441-491
Specificity
This antibody detects endogenous levels of EST4A at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.87% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES6, encodes a secreted enzyme, and may play a role in the detoxification of drugs and xenobiotics in neural and other tissues of the body and in the cerebrospinal fluid. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature and/or biological validity of some variants have not been determined. [provided by RefSeq, Jun 2010],
Function
function:Probable carboxylesterase.,similarity:Belongs to the type-B carboxylesterase/lipase family.,
Gene Name
CES4A CES8 UNQ440/PRO873
Other name
Carboxylesterase 4A (EC 3.1.1.-)
Human protein sequence Database
Q5XG92
Mouse protein sequence database
Q8R0W5
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Blood,Brain,Uterus,
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