Immunogen
Synthesized peptide derived from human Chromogranin A
Specificity
The antibody can specifically recognize human Chromogranin A protein.
Source
Mouse, Monoclonal/IgG1, Kappa
Formulation
PBS, pH7.2, 0.03% Porcolin 300, containing stabilizing protein
Dilution rate
IHC-p 1:200-400,
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014],
Function
function:Pancreastatin strongly inhibits glucose induced insulin release from the pancreas.,miscellaneous:Binds calcium with a low-affinity.,PTM:Sulfated on tyrosine residues and/or contains sulfated glycans.,similarity:Belongs to the chromogranin/secretogranin protein family.,subcellular location:Neuroendocrine and endocrine secretory granules.,
Protein name
beta Granin;betagranin (N-terminal fragment of chromogranin A);catestatin;CgA;CHG A;Chga;chromofungin;Chromogranin A;Chromogranin A parathyroid secretory protein 1;Chromogranin A precursor;Chromograni
Abbreviation
Chromogranin A
Other name
beta Granin;betagranin (N-terminal fragment of chromogranin A);catestatin;CgA;CHG A;Chga;chromofungin;Chromogranin A;Chromogranin A parathyroid secretory protein 1;Chromogranin A precursor;ChromograninA;CMGA_HUMAN;ER-37;Pancreastatin;Parastatin;Parathyroid secretory protein 1;Pituitary secretory protein I;Secretory protein I;SP I;SP-I;SP1;SPI;vasostatin 2;Vasostatin;Vasostatin I;Vasostatin II;vasostatin-2
Human protein sequence Database
P10645
Mouse protein sequence database
P26339
Rat protein sequence database
P10354
Cellular localization
Cytoplasmic
Tissue expression
Pancreas/ stomach
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