Molecular weight (DA)
60kD
Immunogen
Synthesized peptide derived from human NRAM2 AA range: 474-524
Specificity
This antibody detects endogenous levels of NRAM2 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.156% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010],
Function
disease:Defects in SLC11A2 are a cause of hypochromic microcytic anemia [MIM:206100]. The disease is characterized by an abnormal hemoglobin content in the erythrocytes which are reduced in size. It may be hereditary or acquired. Mutations in SLC11A2 are associated with progressive liver iron overload and normal to moderately elevated serum ferritin levels.,function:Macrophage-specific membrane transport. Important in metal transport, in particular iron.,similarity:Belongs to the NRAMP family.,tissue specificity:Expressed at low levels in all tissues analyzed.,
Gene Name
SLC11A2 DCT1 DMT1 NRAMP2 OK/SW-cl.20
Other name
Natural resistance-associated macrophage protein 2 (NRAMP 2) (Divalent cation transporter 1) (Divalent metal transporter 1) (DMT-1)
Fields
>>Lysosome;>>Ferroptosis;>>Mineral absorption;>>Alzheimer disease;>>Parkinson disease
Human protein sequence Database
P49281
Mouse protein sequence database
P49282
Rat protein sequence database
O54902
Cellular localization
[Isoform 2]: Cell membrane ; Multi-pass membrane protein . Early endosome .; Endosome membrane ; Multi-pass membrane protein . Mitochondrion outer membrane ; Multi-pass membrane protein. Cell membrane ; Multi-pass membrane protein . Also found in extracellular vesicles different from exosomes. .
Tissue expression
Ubiquitously expressed. Isoform 1 is highly expressed in brain. Isoform 2 is highly expressed in spleen, thymus and pancreas. Isoform 3 and isoform 4 are abundantly expressed in duodenum and kidney.
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