Immunogen
Synthesized peptide derived from human SKAP AA range: 34-84
Specificity
This antibody detects endogenous levels of human SKAP
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Gene Name
SKAP C15orf23 TRAF4AF1 HSD11
Protein name
Small kinetochore-associated protein (SKAP) (Kinetochore-localized astrin-binding protein) (Kinastrin) (TRAF4-associated factor 1)
Human protein sequence Database
Q9Y448
Mouse protein sequence database
Q9D9Z1
Rat protein sequence database
Q6AXN6
Cellular localization
Nucleus . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, microtubule organizing center . Colocalizes with microtubules around centrosomes in prophase and with the mitotic spindle at prometaphase and metaphase. From late prometaphase to anaphase, is highly concentrated on kinetochores. Located at the kinetochore-microtubule interface. The astrin (SPAG5)-kinastrin (SKAP) complex localizes to the microtubule plus ends (PubMed:23035123). .
Tissue expression
Widely expressed, including in skin.
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