Molecular weight (DA)
60kD
Immunogen
Synthesized peptide derived from human LAT4 AA range: 122-172
Specificity
This antibody detects endogenous levels of LAT4 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.167% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the L-amino acid transporter-3 or SLC43 family of transporters. The encoded protein mediates sodium-, chloride-, and pH-independent transport of L-isomers of neutral amino acids, including leucine, phenylalanine, valine and methionine. This protein may contribute to the transfer of amino acids across the placental membrane to the fetus. [provided by RefSeq, Mar 2016],
Function
function:Sodium-, chloride, pH-independent high affinity transport of large neutral amino acids.,PTM:Glycosylated.,similarity:Belongs to the SLC43A transporter (TC 2.A.1.44) family.,tissue specificity:Detected in several tissues with, higher expression in placenta, kidney and peripheral blood leukocytes. In the kidney is detected in epithelial cells of the distal tubule and collecting duct. In the intestin is expressed mainly in crypt cells of the intestinal microvilli ans epithelial cells in the base of the villus.,
Gene Name
SLC43A2 LAT4 PP7664
Other name
Large neutral amino acids transporter small subunit 4 (L-type amino acid transporter 4) (Solute carrier family 43 member 2)
Human protein sequence Database
Q8N370
Mouse protein sequence database
Q8CGA3
Rat protein sequence database
Cellular localization
Membrane ; Multi-pass membrane protein .
Tissue expression
Detected in several tissues with higher expression in placenta, kidney and peripheral blood leukocytes. In the kidney, is detected in epithelial cells of the distal tubule and collecting duct. In the intestine, is expressed mainly in crypt cells of the intestinal microvilli and epithelial cells in the base of the villus.
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