Immunogen
Synthesized peptide derived from human ASCC1 AA range: 289-339
Specificity
This antibody detects endogenous levels of ASCC1 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011],
Function
function:Enhances NF-kappa-B, SRF and AP1 transactivation.,similarity:Contains 1 KH domain.,subunit:Part of TRIP4 complex, that contains ASCC1, ASCC2 and ASCC3.,tissue specificity:Ubiquitous.,
Human protein sequence Database
Q8N9N2
Mouse protein sequence database
Q9D8Z1
Rat protein sequence database
Cellular localization
Nucleus . Nucleus speckle . Colocalizes with PRPF8 in nuclear speckles in the absence of DNA damage. .
Tissue expression
Ubiquitous.
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