Molecular weight (DA)
105kD
Immunogen
Synthesized peptide derived from human OSBL1 AA range: 229-279
Specificity
This antibody detects endogenous levels of OSBL1 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.209% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms. [provided by RefSeq, Jul 2008],
Function
function:Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate.,similarity:Belongs to the OSBP family.,similarity:Contains 1 PH domain.,similarity:Contains 3 ANK repeats.,subunit:Interacts with VAPA.,
Gene Name
OSBPL1A ORP1 OSBP8 OSBPL1 OSBPL1B
Other name
Oxysterol-binding protein-related protein 1 (ORP-1) (OSBP-related protein 1)
Human protein sequence Database
Q9BXW6
Mouse protein sequence database
Q91XL9
Rat protein sequence database
Q8K4M9
Cellular localization
Late endosome . Colocalizes with RAB7A, RAB9A and LAMP1 in late endosomes.
Tissue expression
Bone,Brain,Embryo,Epithelium,Kidney,Pancreas,Testicle,
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