Molecular weight (DA)
105kD
Immunogen
Synthesized peptide derived from human INT7 AA range: 364-414
Specificity
This antibody detects endogenous levels of INT7 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.258% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a subunit of the integrator complex. The integrator complex associates with the C-terminal domain of RNA polymerase II and mediates 3'-end processing of the small nuclear RNAs U1 and U2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],
Function
function:Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.,sequence caution:Translated as Cys.,similarity:Belongs to the Integrator subunit 7 family.,subunit:Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.,
Other name
Integrator complex subunit 7 (Int7)
Human protein sequence Database
Q9NVH2
Mouse protein sequence database
Q7TQK1
Rat protein sequence database
Cellular localization
Nucleus . Chromosome . Cytoplasm . Localizes to sites of DNA damage in a H2AX-independent manner.
Tissue expression
Skin,Testis,Uterus,
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