Molecular weight (DA)
105kD
Immunogen
Synthesized peptide derived from human SNX13 AA range: 602-652
Specificity
This antibody detects endogenous levels of SNX13 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.277% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. [provided by RefSeq, Jul 2008],
Function
function:May be involved in several stages of intracellular trafficking. Act as a GAP for Galphas.,similarity:Belongs to the sorting nexin family.,similarity:Contains 1 PX (phox homology) domain.,similarity:Contains 1 PXA domain.,similarity:Contains 1 RGS domain.,
Other name
Sorting nexin-13 (RGS domain- and PHOX domain-containing protein) (RGS-PX1)
Human protein sequence Database
Q9Y5W8
Mouse protein sequence database
Q6PHS6
Rat protein sequence database
Cellular localization
Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side .
Tissue expression
Amygdala,Brain,Placenta,Testis,
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