Molecular weight (DA)
105kD
Immunogen
Synthesized peptide derived from human GMIP AA range: 421-471
Specificity
This antibody detects endogenous levels of GMIP at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.282% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the ARHGAP family of Rho/Rac/Cdc42-like GTPase activating proteins. The encoded protein interacts with the Ras-related protein Gem through its N-terminal domain. Separately, it interacts with RhoA through a RhoGAP domain, and stimulates RhoA-dependent GTPase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],
Function
function:Stimulates, in vitro and in vivo, the GTPase activity of RhoA.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 Rho-GAP domain.,subunit:Interacts with GEM through its N-terminal.,
Other name
GEM-interacting protein (GMIP)
Human protein sequence Database
Q9P107
Mouse protein sequence database
Q6PGG2
Rat protein sequence database
Cellular localization
intracellular,cytosol,
Tissue expression
Brain,Leukemia,Platelet,
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