Molecular weight (DA)
105kD
Immunogen
Synthesized peptide derived from human S26A8 AA range: 82-132
Specificity
This antibody detects endogenous levels of S26A8 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.284% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the SLC26 gene family of anion transporters. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. The expression of this gene appears to be restricted to spermatocytes. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2010],
Function
caution:Was originally (Ref.3, AAO26699) thought to originate from mouse.,function:Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility.,induction:Repressed by tunicamycin, an inhibitor of N-glycosylation.,miscellaneous:Activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anionic channels and transporters), gluconate, and by thiosulfate.,PTM:N-glycosylated.,similarity:Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.,
Other name
Testis anion transporter 1 (Anion exchange transporter) (Solute carrier family 26 member 8)
Human protein sequence Database
Q96RN1
Mouse protein sequence database
Q8R0C3
Rat protein sequence database
Cellular localization
Membrane ; Multi-pass membrane protein . Located at the annulus ring structure within the sperm cell. .
Tissue expression
Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell. Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring the spermatocytes and spermatids. Expressed in spermatozoa.
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