Immunogen
Synthesized peptide derived from human EPPI AA range: 55-105
Specificity
This antibody detects endogenous levels of EPPI at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. The protein can inhibit human sperm motility and exhibits antimicrobial activity against E. coli, and polymorphisms in this gene are associated with male infertility. Read-through transcription also exists between this gene and the downstream WFDC6 (WAP four-disulfide core domain 6) gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014],
Function
similarity:Contains 1 BPTI/Kunitz inhibitor domain.,similarity:Contains 1 WAP domain.,tissue specificity:Expressed in epididymis and testis.,tissue specificity:Ubiquitously expressed, but the highest levels are found in epididymis, testis and trachea.,
Gene Name
EPPIN SPINLW1 WAP7 WFDC7
Human protein sequence Database
O95925
Mouse protein sequence database
Q9DA01
Rat protein sequence database
D4A2Z2
Cellular localization
[Isoform 1]: Secreted. Cell surface. Bound to the surface of testicular and on the head and tail of ejaculate spermatozoa.
Tissue expression
In testis, expressed and secreted by Sertoli cells, appearing on the surface of testicular and ejaculate spermatozoa. Expressed in the spermatogonia and the earliest preleptotene spermatocytes. In the epididymis, is expressed and secreted by epithelial cells and covers the surface of epididymal spermatozoa and ciliated epithelial cells (at protein level). Expressed specifically in epididymis and testis. Isoform 2 is expressed only in the epididymis. Weak expression is detected in myoid cells as well as spermatogenic cells.
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