Immunogen
Synthesized peptide derived from human KLHL2 AA range: 521-571
Specificity
This antibody detects endogenous levels of KLHL2 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
function:May play a role in organizing the actin cytoskeleton of the brain cells.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 6 Kelch repeats.,subunit:Binds actin.,tissue specificity:Predominantly expressed in brain.,
Human protein sequence Database
O95198
Mouse protein sequence database
Q8JZP3
Rat protein sequence database
Cellular localization
Cytoplasm, cytoskeleton. Cell projection, ruffle. Cell projection . Cell projection, lamellipodium . Cytoplasm, cytosol. A proportion colocalizes with the actin cytoskeleton. When over-expressed, colocalizes with NPTXR in perinuclear aggresomes (By similarity). .
Tissue expression
Ubiquitous. Detected throughout the brain.